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Marcelo G Kazanietz Selected Research

Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)

11/2021FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.
1/2020Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer.
6/2018P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.
7/2016C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
1/2016Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.
5/2013Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.
10/2012Rho GEFs and cancer: linking gene expression and metastatic dissemination.
2/2012Rac signaling in breast cancer: a tale of GEFs and GAPs.

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Marcelo G Kazanietz Research Topics

Disease

49Neoplasms (Cancer)
12/2022 - 05/2003
21Prostatic Neoplasms (Prostate Cancer)
10/2020 - 01/2002
20Breast Neoplasms (Breast Cancer)
01/2019 - 10/2002
16Neoplasm Metastasis (Metastasis)
12/2022 - 05/2003
12Carcinogenesis
12/2020 - 07/2004
9Lung Neoplasms (Lung Cancer)
11/2021 - 01/2008
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 02/2008
3Pancreatic Neoplasms (Pancreatic Cancer)
10/2020 - 01/2010
2Adenocarcinoma of Lung
11/2021 - 10/2005
2Severe Acute Respiratory Syndrome
10/2021 - 07/2021
2Coronavirus Infections
10/2021 - 07/2021
2COVID-19
10/2021 - 07/2021
2Carcinoma (Carcinomatosis)
03/2007 - 05/2003
1Colorectal Neoplasms (Colorectal Cancer)
12/2019
1Autoimmune Diseases (Autoimmune Disease)
01/2019
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
01/2019
1Disease Progression
06/2018
1Adenocarcinoma
01/2018
1Colonic Neoplasms (Colon Cancer)
01/2018
1Hypoxia (Hypoxemia)
01/2016

Drug/Important Bio-Agent (IBA)

23Protein Kinase CIBA
01/2019 - 01/2002
19Phorbol EstersIBA
01/2020 - 01/2002
15IsoenzymesIBA
01/2019 - 10/2002
12Monomeric GTP-Binding ProteinsIBA
11/2021 - 02/2008
10Phosphotransferases (Kinase)IBA
12/2022 - 12/2005
10AndrogensIBA
02/2020 - 01/2002
9DiglyceridesIBA
12/2022 - 01/2002
9lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
01/2019 - 07/2004
8Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
11/2021 - 02/2012
7Proteins (Proteins, Gene)FDA Link
10/2020 - 12/2006
7LigandsIBA
06/2018 - 11/2005
7ErbB Receptors (EGF Receptor)IBA
01/2018 - 02/2006
6rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
01/2021 - 07/2005
6phorbolIBA
01/2019 - 10/2005
6GTPase-Activating Proteins (GTPase-Activating Protein)IBA
10/2017 - 02/2006
5Protein Kinase C-epsilonIBA
01/2021 - 01/2012
5Phenobarbital (Luminal)FDA Link
06/2018 - 02/2012
5Protein Kinases (Protein Kinase)IBA
01/2018 - 11/2003
4Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2021 - 12/2010
4GTP Phosphohydrolases (GTPases)IBA
10/2020 - 10/2012
4Neuregulin-1 (Neuregulin 1)IBA
06/2018 - 05/2013
4Epidermal Growth Factor (EGF)IBA
06/2018 - 02/2006
4histidine-rich proteinsIBA
08/2016 - 02/2006
4Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2013 - 05/2007
3CarcinogensIBA
12/2020 - 01/2017
3Guanosine Triphosphate (GTP)IBA
10/2020 - 07/2005
3Transcription Factors (Transcription Factor)IBA
12/2019 - 01/2016
3Messenger RNA (mRNA)IBA
01/2019 - 12/2006
3Cyclin D1IBA
06/2018 - 07/2005
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2018 - 01/2016
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2018 - 02/2012
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2012 - 08/2010
3beta-chimaerinIBA
09/2009 - 05/2003
2VimentinIBA
01/2022 - 10/2020
2LithiumIBA
10/2021 - 07/2021
2Nucleocapsid ProteinsIBA
10/2021 - 07/2021
2Glycogen Synthase Kinase 3IBA
10/2021 - 07/2021
2Peptide Hydrolases (Proteases)FDA Link
12/2020 - 01/2020
2Biological ProductsIBA
12/2020 - 04/2013
2Benzo(a)pyreneIBA
12/2020 - 03/2007
2Biomarkers (Surrogate Marker)IBA
01/2020 - 01/2018
2Protein Isoforms (Isoforms)IBA
01/2020 - 01/2012
2LactonesIBA
01/2019 - 01/2002
2Small Interfering RNA (siRNA)IBA
06/2018 - 09/2015
2CytokinesIBA
09/2015 - 10/2012
2Antineoplastic Agents (Antineoplastics)IBA
05/2013 - 09/2010
2rho-Associated KinasesIBA
05/2013 - 10/2009
2Estrogen ReceptorsIBA
02/2012 - 11/2003
2Protein Kinase C-deltaIBA
01/2010 - 11/2005
2Androgen Receptors (Androgen Receptor)IBA
03/2009 - 12/2006
2p38 Mitogen-Activated Protein KinasesIBA
03/2009 - 09/2003
2heregulin beta1IBA
02/2008 - 02/2006
2Mitogen-Activated Protein KinasesIBA
01/2005 - 11/2003
1Type C PhospholipasesIBA
12/2022
1EnzymesIBA
12/2022
1Antiviral Agents (Antivirals)IBA
07/2021
1Glycogen Synthase (Synthase I)IBA
07/2021
1RNA (Ribonucleic Acid)IBA
12/2020
1Guanosine Diphosphate (GDP)IBA
10/2020
1CalciumIBA
02/2020
1MicroRNAs (MicroRNA)IBA
12/2019
1Myristic Acid (Tetradecanoic Acid)IBA
01/2019
1Acetates (Acetic Acid Esters)FDA Link
01/2019
1Chemotactic FactorsIBA
01/2019
1Transforming Growth Factor beta (TGF-beta)IBA
01/2019
1ChemokinesIBA
01/2019
1Insulin-Like Growth Factor I (IGF-1)IBA
06/2018
1Pharmaceutical PreparationsIBA
01/2018
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2018
1Dinoprostone (PGE2)FDA Link
01/2018
1Caspase 3 (Caspase-3)IBA
01/2018
1Ribosomal RNAIBA
01/2017
1Rho Guanine Nucleotide Exchange FactorsIBA
01/2017
1Matrix Metalloproteinase 10 (Stromelysin 2)IBA
08/2016
1NucleotidesIBA
08/2016
1Indicators and Reagents (Reagents)IBA
01/2016
1Tyrosine Kinase InhibitorsIBA
05/2015
1Erlotinib Hydrochloride (CP 358,774)FDA Link
05/2015

Therapy/Procedure

15Therapeutics
12/2022 - 07/2004
1Immunotherapy
12/2022